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有請聰明大大幫幫忙!!~~~ 翻譯一下

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Furthermore,worm-modulatedIL-10-producingBcellsfromIL-4deficientmice,confercompleteresistancetoanaphylaxiswhentransferredtona?vemice[9].Inaddition,innateCD25?CD4?regulatorycellshavebeenrecentlyshowntocontributetoTh2polarizationduringhelminthinfectionsbyspecifically...顯示更多Furthermore,worm-modulatedIL-10-producingBcellsfromIL-4deficientmice,confercompleteresistancetoanaphylaxiswhentransferredtona?vemice[9].Inaddition,innateCD25?CD4?regulatorycellshavebeenrecentlyshowntocontributetoTh2polarizationduringhelminthinfectionsbyspecificallysuppressionofTh1developmentbymaturedendriticcells[10,11].Thisregulatorynetworkproducedbyapersistentimmunechallenge,wouldofferunifyingexplanationsfortheinverseassociationofparasiticinfectionsandallergicdiseases[12].Paradoxically,allergicreactionshavebeendescribedagainsttheseimmunimodulatoryparasiticallergens[13,14].Themorbilityandseverityofhelminthinfectionshavebeendrasticallyreducedinwesternizedcountries,butformanyyearslittleinteresthasbeenpaidtoclinicalallergicresponsestocertainparasites,whicharestillprevalentinmodernizedcountries.HumaninfectionbyAnisakissimplex,hasbecomefrequentnowadaysduetotheoverallhighrateoffishcontaminationandtheneweatinghabits.Thishelminthinfectionhasastrongimpactinallergy[13,15–19].InSpain,ithasbeenestimatedthatA.simplexallergymaybemoreprevalentthananyspecificfoodallergyintheadultpopulation[20]andcompromisesasmuchas10%oftheidiopathicanaphylaxis.Inaddition,ahighrate(13%)ofblooddonorsaresensitizedtotheselarvalproteins[21]aswellas50%ofthefishmongersandthefishermeninItaly[22].IntheMadridarea,23%ofthepatientsattendingtoanallergyclinicaresensitizedtoA.simplex[18].Curiously,only20%ofthemdevelopallergicreactions.SomeA.simplexallergensarebeingidentified[23–26].

最佳解答

此外，蠕蟲調整IL 10生產b细胞由IL-4短少老鼠，商談對過敏症的完全抵抗，当轉移到na?ve老鼠[9]。另外，固有CD25?CD4?管理細胞由Th1由成熟樹狀細胞[10,11的]發展鎮壓最近顯示明確地造成Th2極化在蠕蟲傳染期間。一個堅持免疫挑戰导致的這個管理網絡，將提供寄生傳染和過敏疾病[12的]相反協會的統一的解釋。似是而非地，过敏反应被描述了反對這些immunimodulatory寄生變態反應原[13,14]。蠕蟲傳染morbility和嚴肅在被西化的國家激烈地減少了，但是許多年一点利息被付了對對某些寄生生物的臨床過敏反應，是流行在現代化的國家。由Anisakis單工通信制的人的傳染，現今有成為的頻繁由于魚汙穢和新的饮食习惯的整體高速率。這蠕蟲傳染有強的衝擊在過敏[13,15-19]。在西班牙，估計A.單缸過敏比在成人人口[20]和妥協的所有具體食物过敏也许流行多达10%先天過敏症。另外，一種高速率(13%)的输血人使敏感對這些幼蟲蛋白質[21]並且50%魚販子和漁夫在意大利[22]。在馬德里地区，出席過敏診所的23%患者使敏感對A.單工通信制[18]。好奇地，仅20%他們开发过敏反应。一些A.單缸變態反應原被辨認[23-26]。

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